A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element.

Lineage-selective expression of developmental genes is dependent on the interplay between activating Lamp Table and repressive mechanisms.Gene activation is dependent on cell-specific transcription factors that recognize transcriptional enhancer sequences.Gene repression often depends on the recruitment of Polycomb group (PcG) proteins, although th

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